Science Lab

Mission Statement

To fund ground-breaking research aimed at stopping the progression of ALS in patients and reverse the damage it caused.

About the Foundation

The Calcagnini ALS Foundation raises funds for research and developing strategies to treat people with ALS. Our partners identify specific immune system irregularities and cell anomalies related to ALS and take action based on the findings. We focus on funding identified solutions to cure this disease.

Science Lab

What is ALS?

Amyotrophic Lateral Sclerosis, also called ALS or Lou Gehrig's disease, is a progressive, degenerative neuromuscular disease that affects the nerve cells in the brain and spinal cord. These motor neurons carry messages from the brain to the spinal cord and, ultimately, to the muscles that are necessary for voluntary and involuntary movement and function.


Our Story

In July of 2017, James Calcagnini learned that he had ALS. Initially devastated by the diagnosis, James and his wife, DeAnne, quickly pivoted into a call to action to fight the disease. With no known cure for ALS, and available treatment options that only marginally slow its progression, they began aggressively exploring novel approaches to discover a cure.

Because ALS is an autoimmune disease, James and DeAnne focused on the immune system and expert researchers working in that field. Their search, aided by James’ identical twin brother, Tom, led them to Dr. Anahid Jewett, a world-renowned immunologist at the University of California Los Angeles (UCLA).

Over the last four years, Dr. Jewett has extensively analyzed James’ immune system and compared it with that of Tom, who does not have ALS. This has enabled her to analyze James’ immune system and identify how it differs from that of a healthy control, a strategy unique to Dr. Jewett’s research.

The goal of the Calcagnini ALS Foundation is to raise funds to expand on Dr. Jewett’s significant breakthroughs and discoveries, and to develop treatment strategies and diagnostic tools to help mitigate this horrific affliction.

Dr. Anahid Jewett

Professor and Director of Tumor Immunology Laboratory
Division of Oral Biology and Medicine
The Jane and Jerry Weintraub Center for Reconstructive Biotechnology
Jonsson Comprehensive Cancer Center
UCLA School of Dentistry and Medicine

Contact Calcagnini ALS Foundation

Calcagnini ALS Foundation, Inc.

A Charitable 501(c)3 Non-Profit Corporation

Tax ID# 85-2164578

Address: 528 Chapel Street New Haven, CT 06511

Phone Office: (203) 773-1113